For acute anxiety requiring a benzodiazepine, short-acting agents such as oxazepam or lorazepam are preferred. A pooled analysis found that maternal use of paroxetine usually produced undetectable or low drug concentrations in infant serum this agent may be an option when initiating therapy for generalized anxiety disorder (GAD) in a breast-feeding mother. Due to individual variability in the response to anxiolytics, it may be prudent to continue the existing regimen with caution if ongoing treatment is deemed necessary during breast-feeding. There is often a lack of information regarding anxiolytic use during breast-feeding. Buspirone and its metabolites are excreted in the milk of lactating rats. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. Buspirone should be avoided during breast-feeding if clinically possible the extent of excretion of buspirone and its active metabolite into human milk is not known.
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